The authors thank Covi Amanda and Paneda Roberts for assist with indirect calorimetry

The authors thank Covi Amanda and Paneda Roberts for assist with indirect calorimetry. Footnotes The authors declare no conflict appealing. This post contains supporting information online at www.pnas.org/cgi/content/full/0711808105/DCSupplemental.. or in degrees of 0.05). Acylated, however, not = 0.07). Oddly enough, studies demonstrated which the catalytic activity of GHR-11E11 was completely abrogated in the current presence […]

IC50 was not reached in LR5 cells

IC50 was not reached in LR5 cells. MM cell lines.(PDF) pone.0050005.s003.pdf (14K) GUID:?EB09D843-51F5-4AF9-B915-FA22CF004561 Abstract The PI3K/Akt/mTOR signal transduction pathway plays a central role in multiple myeloma (MM) disease progression and development of therapeutic resistance. mTORC1 inhibitors have shown limited efficacy in the clinic, largely attributed to the reactivation of Akt due to rapamycin induced mTORC2 […]