In contrast, pathways such as mitotic roles of Polo-like kinase, Rac signaling, aryl hydrocarbon receptor signaling, GM-CSF signaling, and CD40 signaling were activated or had a trend towards activation in doxorubicin-treated MCF7/LMTK3 cells compared to MCF7 (Fig

In contrast, pathways such as mitotic roles of Polo-like kinase, Rac signaling, aryl hydrocarbon receptor signaling, GM-CSF signaling, and CD40 signaling were activated or had a trend towards activation in doxorubicin-treated MCF7/LMTK3 cells compared to MCF7 (Fig. a mouse model we showed that ectopic overexpression of LMTK3 decreases the efficacy of doxorubicin in reducing tumor […]

Yeku et al used CAR-T cells to autocrine IL-12 to make CAR-T cells have stronger proliferation capacity and persistence in the body

Yeku et al used CAR-T cells to autocrine IL-12 to make CAR-T cells have stronger proliferation capacity and persistence in the body.21 Adachi et al designed CAR-T cells that secrete IL-7 and CCL19 at the same time and proved that they not only make CAR-T cells more proliferative but also increase the tumor infiltration ability […]